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Medical Studies

CO2 therapy in clinical trials has proven effective, as documented by a large number of studies.

Several studies have shown its potential to improve the  ability to withstand effort in activity and sports recovery.


Clinical and microcirculatory effects of transcutaneous CO2 therapy in intermittent claudication. Randomized double-blind clinical trial with a parallel design.
A clinical trial,  carried out in 2009,  randomised   62 patients with intermittent claudication (100-500 meters) to 18 consecutive days of CO2treatment or placebo (air).  The study demonstrated that 18 consecutive days of percutaneous CO2treatment significantly increased walking distance in patients with moderate intermittent claudication. This effect, associated with an increase in peripheral systolic pressure and PO2, is evidence of a better ability to withstand effort.  (Fabry R, Monnet P, Schmidt J, Lusson JR, Carpentier PH, Baguet JC, Dubray C;  Clinical and microcirculatory effects of transcutaneous CO2 therapy in intermittent claudication. Randomized double-blind clinical trial with a parallel design; 2009)


Further studies

A novel system for transcutaneous application of carbon dioxide causing an "artificial Bohr effect" in the human body.
2011

The effect of transcutaneous application of carbon dioxide (CO2) on skeletal muscle.
2011

CO2-induzierte Zunahme der akralen Durchblutung und des Sauerstoffpartialdruckes bei arterieller Verschlußkrankheit
1991

Effects of Serial Percutaneous Application of Carbon Dioxide in Intermittent Claudication: Results of a Controlled Trial
1990

The effects of external CO2 application on human skin microcirculation investigated by laser Doppler flowmetry
1985

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Huch A., Huch R., Rooth G.: Continuous Transcutaneous Monitoring. Plenum Press: New York
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